Coronary artery disease
Coronary artery disease (CAD) is the leading cause of mortality globally.
CAD is asymptomatic in most of the population. When severe enough it can cause angina, or an acute coronary syndrome including myocardial infarction. CAD may also present with heart failure or sudden cardiac death.
CAD is primarily due to atherosclerosis, an inflammatory process that leads to atheroma development and remodelling/stenosis of the coronary arteries. A stenosis of >50% of diameter or >75% cross section diameter reduction can lead to angina. Thrombus formation after plaque disruption can lead to acute coronary syndrome 1,2.
- non-modifiable: family history, age, male sex 1
- modifiable: hypercholesterolaemia, left ventricular hypertrophy, obesity, hypertension, diabetes sedentary lifestyle, smoking, alcohol 1
There are a variety techniques to image coronary artery disease including both anatomical and functional modalities. Coronary angiography has been the mainstay for many years, but in certain patient groups is being replaced by non-invasive imaging such as coronary CT angiography (cCTA).
There are several appropriate clinical indications for the performance of coronary CTA 8:
- acute chest pain in patients with low-to-intermediate pretest probability of CAD
- evaluation of coronary anatomy and bypass grafts
- assessment of congenital heart diseas
- coronary artery calcium scoring
- patients with technically limited images from echocardiography or MRI
Haemodynamically significant stenoses are those >70% for all coronary arteries, except the left main coronary artery where >50% stenosis is considered significant 7.
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- 6. Sayols-Baixeras S, Lluís-Ganella C, Lucas G et-al. Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants. Appl Clin Genet. 2014;7: 15-32. doi:10.2147/TACG.S35301 - Free text at pubmed - Pubmed citation
- 7. Abbara S, Miller SW. Cardiac Imaging: The Requisites. Mosby. ISBN:0323055273. Read it at Google Books - Find it at Amazon
- 8. Schroeder S, Achenbach S, Bengel F, Burgstahler C, Cademartiri F, de Feyter P, George R, Kaufmann P, Kopp AF, Knuuti J, Ropers D, Schuijf J, Tops LF, Bax JJ; Working Group Nuclear Cardiology and Cardiac CT; European Society of Cardiology; European Council of Nuclear Cardiology. Cardiac computed tomography: indications, applications, limitations, and training requirements: report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT of the European Society of Cardiology and the European Council of Nuclear Cardiology. Eur Heart J. 2008 Feb;29(4):531-56. Epub 2007 Dec 15. DOI: 10.1093/eurheartj/ehm544