Cotswolds-modified Ann Arbor classification
Citation, DOI & article data
The Cotswolds-modified Ann Arbor classification is a lymphoma staging classification system for both Hodgkin lymphoma and non-Hodgkin lymphoma. They came about in 1988 following recommended modifications to the Ann Arbor staging system after a meeting in Cotswold, England.
stage I: one nodal group or lymphoid organ (e.g. spleen or thymus)
- stage IE: one extranodal site
stage II: two or more nodal groups, same side of the diaphragm
- stage IIE: localized extranodal site with stage II criteria, both on the same side of the diaphragm
stage III: nodal groups on both sides of the diaphragm
- stage IIIS(1): with splenic involvement
- stage IIIE(2): with localized extranodal site
- stage IIISE: both
- stage IV: disseminated involvement of one or more extralymphatic organ (e.g. lung, bone) with or without any nodal involvement
Additional sub-staging variables:
- 1. Olweny CL. Cotswolds modification of the Ann Arbor staging system for Hodgkin's disease. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 1990 Sep;8(9):1598.