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Cowdry bodies are eosinophilic or basophilic neuronal intranuclear inclusions composed of nucleic acid and protein, this cytopathic changes are considered a hallmark of viral infection.1.
Cowdry bodies are in fact fixation artifacts and not directly the result of the intracellular virus. 2 There are two types of intranuclear Cowdry bodies:
- Type A: acidophilic material of droplet-like masses surrounded by clear halos within nuclei., seen in gingivostomatitis and conjunctivitis caused by Herpes simplex virus and also chicken pox caused by varicella zoster. 3
- Type B intranuclear eosinophilic without any nuclear change, seen in infection with poliovirus and CMV.
Cowdry bodies are named after the Canadian-American biologist Edmund Vincent Cowdry Ph.D., 1888-1975
- 1. Kumar V, Abbas AK, Aster JC. Robbins and Cotran pathologic basis of disease. Saunders. ISBN:B00LEDJK76. Read it at Google Books - Find it at Amazon
- 2. Chou SM, Cherry JD. Ultrastructure of Cowdry type A inclusions. 1. In human herpes simplex encephalitis. (1967) Neurology. 17 (6): 575-86 passim. Pubmed
- 3. Balachander N, Rajesh E, Priya S. H, Masthan K. M. K. Inclusion Bodies. Biomed Pharmacol J 2016;9(2). DOI: https://dx.doi.org/10.13005/bpj/1013