Citation, DOI, disclosures and article data
Citation:
Bell D, Yap J, Vadera S, et al. Crouzon syndrome. Reference article, Radiopaedia.org (Accessed on 25 Jan 2025) https://doi.org/10.53347/rID-14787
Crouzon syndrome, also known as craniofacial dysotosis, is rare disorder characterized by premature craniosynostoses.
Features include:
Genetics
It carries an autosomal dominant inheritance due to a mutation in fibroblast growth factor receptor 2 (FGFR2) gene on chromosome 10q25-26.
Associations
History and etymology
It is named after L E Octave Crouzon, French physician who first described the condition in 1912 7.
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1. Chen C, Lin S, Su Y, Huang J, Wang W. A Cloverleaf Skull Associated with Crouzon Syndrome. Arch Dis Child Fetal Neonatal Ed. 2006;91(2):F98. doi:10.1136/adc.2005.087577 - Pubmed
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2. Michael Entezami, Ursula Knoll, Matthias Albig et al. Ultrasound Diagnosis of Fetal Anomalies. (2004) ISBN: 9781588902122 - Google Books
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3. Lowe L, Booth T, Joglar J, Rollins N. Midface Anomalies in Children. Radiographics. 2000;20(4):907-22; quiz 1106-7, 1112. doi:10.1148/radiographics.20.4.g00jl07907 - Pubmed
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4. Altintas A, Gül Aksoy F, Altintas C, Midillioglu I, Duman S. Evaluation of Findings in Crouzon's Syndrome. Orbit. 1999;18(4):247-59. doi:10.1076/orbi.18.4.247.2696 - Pubmed
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5. Leo M, Suslak L, Ganesh V, Adhate A, Apuzzio J. Crouzon Syndrome: Prenatal Ultrasound Diagnosis by Binocular Diameters. Obstet Gynecol. 1991;78(5 Pt 2):906-8. - Pubmed
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6. Gollin Y, Abuhamad A, Inati M, Shaffer W, Copel J, Hobbins J. Sonographic Appearance of Craniofacial Dysostosis (Crouzon Syndrome) in the Second Trimester. J Ultrasound Med. 1993;12(10):625-8. doi:10.7863/jum.1993.12.10.625 - Pubmed
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7. L. E. O. Crouzon. Dysostose cranio-faciale héréditaire. Bulletin de la Société des Médecins des Hôpitaux de Paris, 1912, 33: 545-555.
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