Cryoglobulinaemic vasculitis

Cryoglobulinaemic vasculitis (CV) is a form of immune mediated primary vasculitis involving small to medium sized vessels. It may involve multiple organs and can have a range of clinical presentations.

Pathology

Cryoglobulins are immunoglobulins which precipitate when serum is incubated at a temperature lower than the body temperature. Approximately half of patients with cryoglobulinemia have clinical manifestations of systemic vasculitis caused by small-vessel damage as a result of deposition of immune complexes on small vessel walls and following complex activation. 

There are three main types of cryoglobulinemia which are grouped based on the type of antibody produced:

  • type I:
  • type II:
  • type III:

types II and III are also referred to as mixed cryoglobulinemia

type I is most often related to cancer of the blood (b cell lymphoproliferative disorders) or immune systems.

Associations
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Article Information

rID: 46718
Synonyms or Alternate Spellings:
  • Cryoglobulinaemic vasculitis (CV)
  • Essential cryoglobulinaemic vasculitis (CV)
  • Essential cryoglobulinaemic vasculitis
  • Essential cryoglobulinaemia
  • Cryoglobulinaemia

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