CT colonography - pitfalls

Last revised by Dr Henry Knipe on 31 Mar 2019

The interpretation of CT colonography can sometimes be difficult because of pitfalls, which may be a source of false negative and false positive findings. When suboptimal CT colonography techniques are applied, the number and severity of interpretive pitfalls can rapidly multiply. However, when proven state-of-the-art techniques are consistently applied, there are a few potential pitfalls that may be encountered at interpretation. 

Common pitfalls

Sticky solid colonic residue

Frequently the colonic residue remains in the colon adherent to the wall resulting in false-positive interpretation with a pseudo polypoid lesion. The residue is sometimes easy to characterize because of air inclusions and a positional shift between the supine and prone acquisition. However, in case of sticky solid colonic residue, there is no positional shift. 

Solution: Good preparation, which should include a combination of a low-residue diet (no vegetables or fruit during the three days before the examination), and fecal/fluid tagging the day before CT colonography.  Fecal tagging consists of drinking positive contrast (e.g. gastrografin) the day before CT colonography (suggested amount 180 mL of contrast with some water). This allows for differentiation between tagged food residue and a true non-tagged polyp.

Rectal catheter

Visualization of the rectum is hampered by the rectal catheter needed to insufflate the colon with gas.  Also, the balloon may compress luminal lesions against the rectal wall reducing their perception. 

Solution: Meticulous inspection, using 3D endoluminal and 2D views would be of value. This can be done by turning the virtual camera in a retrograde direction to inspect the “peri-catheter” segment. Also, it is advised to deflate the balloon immediately before starting the prone acquisition to avoid compression of lesions by the balloon of the catheter.


The contraction of folds in case of spasm, the folds have thickened appearance. 

Solution: Optimal colonic distension is crucial to flatten the semilunar folds. This can be obtained by combining smooth muscle relaxation, colonic insufflation with a CO2 injector and dual positioning (i.e., acquisition in the supine and prone position).

Flexural pseudotumor

The peri-colonic structures at the inner part of the flexure are compressed and cause a thickening of the fold that may mimic tumoral lesions. 

Solution: The thickening frequently presents with a lipomatous density representing the peri-colonic structures. In 3D, this thickening is regular and smooth. Also, the thickened fold frequently has a different aspect between the supine and prone acquisition.

Enlarged ileocecal valve

The ileocecal valve may be lipomatous (density between 0 and −100 HU) or papillary (mixed density). When enlarged, it gives a pseudotumoral appearance.

Solution: It is mandatory to define the structure of the ileocecal valve by defining both lips of the valve (particularly on coronal reformatted images). Moreover, there is a change in aspect between supine and prone acquisition.

Appendicular impression

The appendicular base may have an impression on the cecal tip. Also, the appendiceal stump can protrude into the cecal lumen giving the appearance of a small pseudo-polypoidal lesion.

Solution: This can be confirmed by localizing the appendix on the coronal and sagittal reformats. Also, the appendiceal orifice can be confirmed on the endoluminal 3D views. Any history of appendectomy can be obtained from the patient before the examination.

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