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They should not be confused with microcystic meningiomas, a distinct variant, in which the cysts are microscopic.
True cystic meningiomas (type 1 and 2 - see below) are those with a few large central cysts and are uncommon. Those with more numerous smaller peripheral cysts are more frequent (8-23% of cases). They are over-represented in male patients and the pediatric population 1.
Patients present clinically in the same way as patients with non-cystic meningiomas, with either symptom related to increased intracranial pressure (ICP), focal neurology, or seizures.
Various mechanisms have been proposed, and probably more than one is applicable depending on the location of the cysts:
- degeneration or necrosis
- direct secretion by meningioma
- reactive changes (peripheral arachnoid cysts)
This classification was initially proposed by Nauta et al. in 1979, which was later modified by Worthington et al. 4 in 1985, which at the time of writing (July 2016) is most widely used classification.
Nauta et al. divided cystic meningiomas into four subtypes according to the location of the cyst with respect to the brain and meningioma 3:
- type 1: intratumoral cyst(s), located centrally within the meningioma
- type 2: intratumoral cyst(s), situated peripherally within the meningioma but still surrounded by tumor
- type 3: cyst wall may contain nest of tumor cells.
- type 4: cyst(s) located within the adjacent brain
- type 5: cyst(s) located between the meningioma and brain (arachnoid cyst)
4th type is most common.
The tumor itself has imaging features identical to non-cystic meningiomas (see the meningioma main article for a full discussion). The cysts are of variable size and can be entirely surrounded by tumor (types 1 or 2) or clearly between the tumor and the brain (type 5) or within the adjacent brain (type 4). On imaging, it is sometimes difficult to distinguish between these types.
The differential is dependant on the location of the tumor. For tumors around the base of the skull, cystic schwannomas (e.g. vestibular schwannoma, trigeminal schwannoma) are the main differential, as they share the bright contrast enhancement, and are commonly cystic when large.
- 1. Buetow MP, Buetow PC, Smirniotopoulos JG. Typical, atypical, and misleading features in meningioma. Radiographics. 1991;11 (6): 1087-106. Radiographics (abstract) - Pubmed citation
- 2. Drevelegas A. Imaging of Brain Tumors with Histological Correlations. Springer Verlag. (2010) ISBN:3540876480. Read it at Google Books - Find it at Amazon
- 3. Nauta HJ, Tucker WS, Horsey WJ et-al. Xanthochromic cysts associated with meningioma. J. Neurol. Neurosurg. Psychiatr. 1979;42 (6): 529-35. doi:10.1136/jnnp.42.6.529 - Free text at pubmed - Pubmed citation
- 4. Worthington C, Caron JL, Melanson D et-al. Meningioma cysts. Neurology. 1986;35 (12): 1720-4. Pubmed citation