Dr Daniel J Bell and Dr Henry Smith et al.

D-dimer is a commonly tested biological marker which is produced by the enzymatic breakdown of cross-linked fibrin which forms the fibrous mesh of a blood clot. The measurement of D-dimer in the circulation acts as a marker of coagulation and fibrinolysis, which can be useful in the diagnosis of multiple diseases.

Validated uses of D-dimer
Unvalidated uses of D-dimer
Conditions associated with a raised D-dimer
Conditions associated with an extremely high D-Dimer

In a recent large study an extreme elevated level was arbitrarily defined as >5,000 µg/L 4. The vast majority of cases were associated with severe disease:

  • malignancy
  • sepsis
  • venous thromboembolism
  • others
    • trauma, surgery, aortic dissection/aneurysm, 

Article information

rID: 61767
System: Vascular
Synonyms or Alternate Spellings:
  • D-dimer greater than 5,000
  • Massive D-dimer
  • Extremely raised D-dimer
  • Grossly raised D-dimer
  • Greatly raised D-dimer
  • Markedly raised D-dimer
  • Greatly elevated D-dimer
  • Very high D-dimer
  • Grossly elevated D-dimer
  • Markedly elevated D-dimer
  • High D-dimer
  • Extremely high D-dimer
  • D dimer

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