Desmin

Last revised by Joachim Feger on 11 Dec 2021

Citation, DOI, disclosures and article data

Citation:

Feger J, Bell D, Baba Y, Desmin. Reference article, Radiopaedia.org (Accessed on 25 Apr 2024) https://doi.org/10.53347/rID-85173

DOI:

https://doi.org/10.53347/rID-85173

Permalink:

https://radiopaedia.org/articles/85173

rID:

85173

Article created:

16 Dec 2020, Joachim Feger ◉

Disclosures:

At the time the article was created Joachim Feger had no recorded disclosures.

View Joachim Feger's current disclosures

Last revised:

11 Dec 2021, Joachim Feger ◉

Disclosures:

At the time the article was last revised Joachim Feger had no recorded disclosures.

View Joachim Feger's current disclosures

Revisions:

5 times, by 3 contributors - see full revision history and disclosures

Systems:

Musculoskeletal

Sections:

Pathology

Synonyms:

Desmin protein

Desmin is a muscle-specific protein. It is the main intermediate filament protein and a key component in the cytoskeletal network of muscle cells e.g. in the myocardium, where it is ampler than in skeletal muscle or smooth muscle. It interacts with other proteins to support the myofibrils at the level of the Z-discs or of the intercalated discs and has a role in mechanochemical signal transmission, power transfer and the maintenance of cellular integrity ^1,2. It also serves as a target in immunohistochemistry where it can be used for the characterisation of muscle tissue and tumours.