Dialysis disequilibrium syndrome

The dialysis disequilibrium syndrome (DDS) is a situation characterised by development of neurological symptoms caused by rapid removal of urea during hemodialysis. It develops primarily from an osmotic gradient that develops between the brain and the plasma as a result of rapid haemodialysis. It usually occurs during the last hour of hemodialysis or thereafter. The diagnosis of DDS in patients with ESRD is mainly based on exclusion of other possible central nervous system disorders 1-2.

Radiographic features

CT / MRI brain

May show evidence of cerebral oedema. ADC values may be increased on MRI.

Histroy and etymology

It was first described by A C Kennedy et al. in 1962 3.

See also

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Article information

rID: 21399
Tag: stub, cases, refs
Synonyms or Alternate Spellings:
  • Dialysis disequilibrium syndrome (DDS)

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