Diffuse large B-cell lymphoma

Last revised by Henry Knipe on 15 Dec 2022

Citation, DOI, disclosures and article data

Citation:

Deng F, Knipe H, Niknejad M, et al. Diffuse large B-cell lymphoma. Reference article, Radiopaedia.org (Accessed on 16 Apr 2024) https://doi.org/10.53347/rID-70781

DOI:

https://doi.org/10.53347/rID-70781

Permalink:

https://radiopaedia.org/articles/70781

rID:

70781

Article created:

4 Sep 2019, Francis Deng ◉

Disclosures:

At the time the article was created Francis Deng had no recorded disclosures.

View Francis Deng's current disclosures

Last revised:

15 Dec 2022, Henry Knipe ◉ ◈

Disclosures:

At the time the article was last revised Henry Knipe had the following disclosures:

Integral Diagnostics, Shareholder (ongoing)
Micro-X Ltd, Shareholder (ongoing)

These were assessed during peer review and were determined to not be relevant to the changes that were made.

View Henry Knipe's current disclosures

Revisions:

11 times, by 10 contributors - see full revision history and disclosures

Systems:

Haematology, Oncology

Tags:

refs, cases

Synonyms:

Diffuse large B-cell lymphoma, not otherwise specified

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma.

Epidemiology

Associations

Diffuse large B-cell lymphoma is sometimes associated with immunodeficiency, including acquired immunodeficiency syndrome.

Pathology

Classification

In the 2016 WHO classification of lymphoid neoplasms, diffuse large B-cell lymphoma, not otherwise specified (NOS), is a type of mature B-cell neoplasm and includes two molecular subgroups indicating the cell of origin:

germinal centre B-cell type
activated B-cell type

In addition, diffuse large B-cell lymphomas with certain molecular/cytogenetic features, previously called "double-hit" or "triple-hit" lymphomas, as well as those resembling Burkitt lymphoma are now classified together as either of the following entities ¹:

There are otherwise multiple specified types of diffuse large B-cell lymphomas: