Diffuse large B cell lymphoma

Diffuse large B cell lymphoma is the most common subtype of non-Hodgkin lymphoma.



Diffuse large B cell lymphoma is sometimes associated with immunodeficiency, including acquired immunodeficiency syndrome.



In 2016 WHO classification of lymphoid neoplasms, diffuse large B cell lymphoma, not otherwise specified (NOS), is a type of mature B cell neoplasm and includes two molecular subgroups indicating cell of origin:

  • germinal center B cell type
  • activated B cell type

In addition, diffuse large B cell lymphomas with certain molecular/cytogenetic features previously called "double-hit" or "triple-hit" lymphomas as well as those resembling Burkitt lymphoma are now classified together as either of the following entities 1:

There are otherwise multiple specified types of diffuse large B cell lymphoma:


See the article on lymphoma staging.

Article information

rID: 70781
Tag: refs, cases
Synonyms or Alternate Spellings:
  • Diffuse large B-cell lymphoma, not otherwise specified

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Cases and figures

  • Case 1
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