Disseminated intravascular coagulation

Dr Daniel J Bell and T K et al.

Disseminated intravascular coagulation (DIC), also known as consumption coagulopathy and defibrination syndrome, refers to a systemic phenomenon of overactivation of coagulation and fibrinolysis.

Clinical presentation

Patients present with bleeding and/or thrombosis, as well as organ-specific sequelae of these processes.



The most common causes of this condition are infection, malignancy, and trauma (including surgery) 1,2.


The diagnosis is supported by laboratory findings of coagulopathy and/or fibrinolysis. These include low platelets, low fibrinogen, elevated D-dimer, prolonged prothrombin time (PT), prolonged international normalized ratio (INR), and prolonged activated partial thromboplastin time (aPTT).

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Article information

rID: 64952
System: Haematology
Synonyms or Alternate Spellings:
  • Consumption coagulopathy and defibrination syndrome
  • DIC

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