Disseminated intravascular coagulation (DIC), also known as consumption coagulopathy and defibrination syndrome, refers to a systemic phenomenon of overactivation of coagulation and fibrinolysis.
Patients present with bleeding and/or thrombosis, as well as organ-specific sequelae of these processes.
The most common causes of this condition are infection, malignancy, and trauma (including surgery) 1,2.
The diagnosis is supported by laboratory findings of coagulopathy and/or fibrinolysis. These include low platelets, low fibrinogen, elevated D-dimer, prolonged prothrombin time (PT), prolonged international normalized ratio (INR), and prolonged activated partial thromboplastin time (aPTT).
- 1. Siegal T, Seligsohn U, Aghai E, Modan M. Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases. (1978) Thrombosis and haemostasis. 39 (1): 122-34. Pubmed
- 2. Spero JA, Lewis JH, Hasiba U. Disseminated intravascular coagulation. Findings in 346 patients. (1980) Thrombosis and haemostasis. 43 (1): 28-33. Pubmed