Disseminated intravascular coagulation

Disseminated intravascular coagulation (DIC), also known as consumption coagulopathy or defibrination syndrome, refers to a systemic phenomenon of overactivation of coagulation and fibrinolysis resulting in widespread clots forming inside blood vessels.

Patients present with bleeding and/or thrombosis, as well as subsequent organ damage.

During homeostasis, there is a balance between coagulation (formation of clots) and fibrinolysis (breakdown of clots). 

During times of stress listed under "Etiology", this homeostasis is disrupted resulting in dysregulated coagulation and fibrinolysis. Widespread clotting occurs exhausting available clotting factors and platelets resulting in excess bleeding. An important mediator in this process is a transmembrane glycoprotein called tissue factor (TF).

The commonest causes of disseminated intravascular coagulation are:

  1. infection and sepsis
  2. malignancy, and
  3. trauma (including surgery) 1,2

The diagnosis is supported by laboratory findings of coagulopathy and/or fibrinolysis including:

Management focuses on treating the underlying condition. Supportive measures include helping the organs that are affected, such as:

  • ventilator support
  • hemodynamic support
  • transfusions (platelets or red blood cells)

Disseminated intravascular coagulation may lead to:

  • ischemia: insufficient blood flow (and subsequent lack of oxygen delivery) to tissue
  • infarction: tissue death (by necrosis) due to inadequate blood supply
  • damage to vital organs e.g. brain, lungs, liver, and kidneys 1

Article information

rID: 64952
System: Haematology
Section: Syndromes
Synonyms or Alternate Spellings:
  • Disseminated intravascular coagulopathy
  • Defibrination syndrome
  • Consumption coagulopathy
  • Disseminated intravascular coagulation (DIC)
  • DIC

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