Disseminated intravascular coagulation

Dr Daniel J Bell and T K et al.

Disseminated intravascular coagulation (DIC), also known as consumption coagulopathy and defibrination syndrome, refers to a systemic phenomenon of overactivation of coagulation and fibrinolysis.

Clinical presentation

Patients present with bleeding and/or thrombosis, as well as organ-specific sequelae of these processes.

Pathology

Etiology

The most common causes of this condition are infection, malignancy, and trauma (including surgery) 1,2.

Markers

The diagnosis is supported by laboratory findings of coagulopathy and/or fibrinolysis. These include low platelets, low fibrinogen, elevated D-dimer, prolonged prothrombin time (PT), prolonged international normalized ratio (INR), and prolonged activated partial thromboplastin time (aPTT).

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Article information

rID: 64952
System: Haematology
Synonyms or Alternate Spellings:
  • Consumption coagulopathy and defibrination syndrome
  • DIC

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