Double inversion recovery sequence

Double inversion recovery (DIR) is a MRI pulse sequence which suppresses signal from the CSF as well as from the white matter and hence enhances any inflammatory lesion.

To obtain such sequence in 3T MRI scanner, two inversion times are required. TI1 which is used for suppression of CSF and usually obtained at 2000-3000 msec and TI2 which is used for white matter at 450 msec.

Its main application is to delineate white matter plaques in multiple sclerosis, estimate lesion load, differentiate juxtacortical from mixed grey matter-white matter plaques and detect infratentorial or spinal cord lesions.


MRI physics
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Article Information

rID: 32070
Section: Physics
Synonyms or Alternate Spellings:
  • Double inversion recovery sequence (DIR)
  • DIR sequence
  • Double inversion recovery (DIR) sequence

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    Case 1: multiple sclerosis in DIR
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