Doubling dose

Last revised by Zemar Vajuhudeen on 14 Jul 2020

Citation, DOI, disclosures and article data

Citation:

Vajuhudeen Z, Doubling dose. Reference article, Radiopaedia.org (Accessed on 22 Mar 2023) https://doi.org/10.53347/rID-80052

DOI:

https://doi.org/10.53347/rID-80052

Permalink:

https://radiopaedia.org/articles/80052

rID:

80052

Article created:

13 Jul 2020, Zemar Vajuhudeen

Disclosures:

At the time the article was created Zemar Vajuhudeen had no recorded disclosures.

View Zemar Vajuhudeen's current disclosures

Last revised:

14 Jul 2020, Zemar Vajuhudeen

Disclosures:

At the time the article was last revised Zemar Vajuhudeen had no recorded disclosures.

View Zemar Vajuhudeen's current disclosures

Revisions:

2 times, by 1 contributor - see full revision history and disclosures

Sections:

Imaging Technology

Synonyms:

Mutation doubling dose

The doubling dose refers to the radiation dose required to double the number of spontaneous genetic mutations in a given population of cells.

The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) have traditionally estimated the doubling dose in humans at 1.0 Gy. A report in 2000 states that this figure is more likely to be 1.5 Gy.

Using data from Japanese atomic bomb survivors and their children, Neel et al (1991) estimate the doubling dose for acute radiation-induced mutations to be between 1.7 and 2.2 Sv, and for chronic radiation-induced mutations to be between 3.4 and 4.5 Sv.