Drug and toxin induced pulmonary hypertension

Last revised by David Luong on 15 Feb 2022

Drug and toxin induced pulmonary hypertension is one of the causes of pulmonary arterial hypertension. It falls under group 1.3 under the Dana point classification system of pulmonary hypertension


A wide range of different drugs have been associated with developing pulmonary hypertension:

  • appetite suppressant drugs: have been withdrawn from the market
    • aminorex
    • fenfluramine derivatives
    • benfluorex
    • phenylpropanolamine
  • amphetamines
  • phentermine
  • mazindol 
  • dasatinib: a dual Src/Abl kinase inhibitor, used in the treatment of chronic myelogenous leukemia 
  • interferon: possible
  • possible agents
    • phenylpropanolamine
    • L-tryptophan
    • certain selective serotonin reuptake inhibitors: pergolide

Radiographic features

Refer to the main article on pulmonary hypertension.

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