Drug and toxin induced pulmonary hypertension

Dr Henry Knipe and Dr Yuranga Weerakkody et al.

Drug and toxin induced pulmonary hypertension is one of the causes of pulmonary arterial hypertension. It falls under group 1.3 under the Dana point classification system of pulmonary hypertension


A wide range of difference drugs have been associated with developing pulmonary hypertension:

  • appetite suppressant drugs: have been withdrawn from the market
    • aminorex
    • fenfluramine derivatives
    • benfluorex
    • phenylpropanolamine
  • amphetamines
  • phentermine
  • mazindol 
  • dasatinib: a dual Src/Abl kinase inhibitor, used in the treatment of chronic myelogenous leukemia 
  • interferon: possible
  • possible agents
    • phenylpropanolamine
    • L-tryptophan
    • certain selective serotonin reuptake inhibitors: pergolide

Radiographic features

Refer to the main article on pulmonary hypertension.

Article information

rID: 37459
System: Chest, Cardiac
Section: Gamuts
Tag: cases
Synonyms or Alternate Spellings:
  • Drug induced pulmonary hypertension
  • Toxin induced pulmonary hypertension
  • Drug and toxin induced pulmonary arterial hypertension

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