Drug and toxin induced pulmonary hypertension is one of the causes of pulmonary arterial hypertension. It falls under group 1.3 under the Dana point classification system of pulmonary hypertension.
A wide range of difference drugs have been associated with developing pulmonary hypertension:
- appetite suppressant drugs: have been withdrawn from the market
- fenfluramine derivatives
- dasatinib: a dual Src/Abl kinase inhibitor, used in the treatment of chronic myelogenous leukemia
- interferon: possible
- possible agents
- certain selective serotonin reuptake inhibitors: pergolide
Refer to the main article on pulmonary hypertension.
- 1. Seferian A, Chaumais MC, Savale L et-al. Drugs induced pulmonary arterial hypertension. Presse Med. 2013;42 (9): e303-10. doi:10.1016/j.lpm.2013.07.005 - Pubmed citation
- 2. Montani D, Seferian A, Savale L et-al. Drug-induced pulmonary arterial hypertension: a recent outbreak. Eur Respir Rev. 2013;22 (129): 244-50. doi:10.1183/09059180.00003313 - Pubmed citation
- 3. Barst RJ, Abenhaim L. Fatal pulmonary arterial hypertension associated with phenylpropanolamine exposure. Heart. 2004;90 (7): e42. doi:10.1136/hrt.2004.036491 - Free text at pubmed - Pubmed citation