Dual energy CT (clinical applications)
Dual-energy CT is becoming increasingly more common in clinical practice due to the rapid rise in computer technology and expanding literature exhibiting vast advantages over conventional single energy CT.
There is a potential to eliminate the need for pre-contrast imaging, using complex subtraction algorithms based on the two datasets known as virtual unenhanced imaging 1.
The acquired images are automatically reconstructed to three separate image sets: 80 kVp, 140 kVp and mixed 80:140 kVp image with the weighting factor of 0.4 (40% image information from the 80 kVp image and 60% information from the 140 kVp image). The weighting factors can be adjusted, to achieve the desired effect. The 80 kVp images have higher contrast attenuation but intrinsically lower signal to noise ratio and smaller field of view. The 140 kVp images have less contrast attenuation but a better signal to noise ratio and a full field of view.
Material decomposition can be further performed on a dedicated workstation to create different image setting including iodine map (virtual contrast image), iodine subtraction (virtual non-contrast image) and bone mask (bone and calcium subtraction). Perfusion and blood volume color coded images can be created by using a grey or color scale. These perfusion and blood volume images reflect the lung perfusion at a single time point. Therefore, they are surrogate perfusion images.
High kVp CT scans have a lower contrast than that of lower kVp due to the K-edge of iodine, giving the lower energy of the dual energy scan an advantage over conventional CT. In fact, the attenuation values of large vessels enhanced with iodine are 70% higher at 80 kVp than at 140 kVp 7.
It isn't unreasonable to assume that you can use single energy scanners at a lower kVp in arterial studies, yet isolated lower kVp scans have a greater noise, while dual-energy CT can be fused with the higher energy scans to compensate.
As mentioned above it is possible to create virtual non-contrast images to delineate dense hematoma from active extravasation of contrast 13.
Bone subtraction techniques in dual-energy CT utilize the same dual attenuation method to remove bony structures more accurately at a set threshold, rather than manual selection in post-processing, this has exceptional advantages when assessing vessels that lie close to skeletal structures 7.
Dual-energy aortogram in surveillance of endovascular aneurysm repair improves detection of endoleaks in fewer acquisitions 7; low kVp scanning can detect subtle leaks, while the virtual non-contrast images replace the unenhanced scan allowing a substantial reduction in radiation burden in patients that require life-long checkups 14,15.
Suboptimal contrast injection
In the event of suboptimal contrast injection and or timing, the lower energy set (closer to the K-edge of iodine) can be favoured to improve the contrast resolution in various studies from pulmonary angiograms to aortograms 8.
Using lower energy data sets are proven to increase the arterial enhancement of pulmonary angiograms and other contrast studies due to the K-edge of iodine being closer to the lower energy used in a dual energy scanner 9-11.
The 80 kVp image has the potential to improve subsegmental pulmonary artery perfusion and distal pulmonary embolus detection 8.
Perfusion blood volume maps can be used to identify the segmental or subsegmental areas of lung affected by a pulmonary embolus. It is important to note that atelectasis, cardiac motion and streak artefact can all cause perfusion defects 9.
Renal stone composition
Renal calculi are composed of different substances such as uric acid, calcium phosphate, calcium oxalate, cystine, and brushite. Clinical management varies by stone type. Dual-energy CT uses advanced post-processing techniques to determine the composition of the calculi accurately, allowing for precise treatment pathways, based on a non-invasive diagnostic test 4,5,16.
For example, if a stone is predominantly made up of uric acid, patients can undergo standard urinary alkalinization rather than have an interventional procedure 17.
The bone mineral can be retrospectively subtracted revealing areas of increased fluid attenuation, providing a notable step forward in the detection of occult fractures 1-5.
Acute bowel ischemia
The addition of iodine maps and 40-keV monoenergetic images to standard single energy CT images was found to increase reader confidence and accuracy in diagnosing acute bowel ischemia. Ischemic segments have been found to have lower densities and iodine concentrations compared to non-ischemic segments 18.
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