Duodenal–jejunal bypass liner
A duodenal–jejunal bypass liner (DJBL), also known as a duodenal–jejunal bypass sleeve device or EndoBarrier™ is being trialled as a new technique, as an alternative to more 'traditional' gastric bypass surgeries 1,2. The basic principle is that the sleeve is endoscopically-inserted into the duodenum with an impervious liner preventing absorption of the chyme by the duodenum or the proximal jejunum.
- 1. Tripolt NJ, Aberer F, Url J, Högenauer C, Schreiber F, Eherer A, Sourij C, Obermayer AM, Stadlbauer V, Svehlikova E, Brunner M, Kojzar H, Pferschy PN, Pieber TR, Sourij H. Impact of Duodeno-Jejunal Bypass Liner (EndoBarrierTM) Implantation on Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus (T2DM): A Study Protocol for a Pilot Trial. (2019) Diabetes therapy : research, treatment and education of diabetes and related disorders. 10 (1): 299-309. doi:10.1007/s13300-018-0540-z - Pubmed
- 2. Glaysher MA, Mohanaruban A, Prechtl CG, Goldstone AP, Miras AD, Lord J, Chhina N, Falaschetti E, Johnson NA, Al-Najim W, Smith C, Li JV, Patel M, Ahmed AR, Moore M, Poulter N, Bloom S, Darzi A, Le Roux C, Byrne JP, Teare JP. A randomised controlled trial of a duodenal-jejunal bypass sleeve device (EndoBarrier) compared with standard medical therapy for the management of obese subjects with type 2 diabetes mellitus. (2017) BMJ open. 7 (11): e018598. doi:10.1136/bmjopen-2017-018598 - Pubmed