Last revised by Dr Mostafa El-Feky on 25 May 2022

Duodenitis is a term given to inflammation of the duodenum.

Duodenitis can result from both intrinsic processes within the duodenum as well as from processes occurring outside the duodenum. It can occur from infective as well as non-infective inflammatory processes.

  • secondary involvement from
  • Crohn disease: duodenal involvement in 0.5-4% of cases
    • primary involvement: ulcer, stricture
    • secondary involvement: enteric fistula
  • duodenal ulcers: occur most frequently in the duodenal bulb
  • AIDS
  • post-radiation therapy
  • Helicobacter pylori: this has shown a near-universal relationship (>90%) with duodenal ulcers, an association with duodenitis remains unproven.
  • giardiasis
  • tropical sprue

Findings include thickening of folds (if present they are almost always found proximal to the ampulla of Vater), nodules or nodular folds, and erosions. Deformity of the duodenal bulb also may be seen.

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Cases and figures

  • Figure 1: CMV duodenitis: histology
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  • Case 1
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