Dynamic contrast enhancement in prostate cancer

Dynamic contrast enhancement (DCE) MRI is emerging as a useful clinical technique as part of a multi-parametric approach for evaluating the extent of primary and recurrent prostate cancer

Protocol and equipment

Typically 3D T1-weighted fast spoiled gradient-echo MRI sequences with an endorectal coil are used to repeatedly image a volume of interest after the administration of a bolus of intravenous contrast agent (Gadolinium).

Image sets are obtained sequentially every few seconds for up to 5-10 minutes. Ideally, acquisitions should be obtained approximately every 5 seconds to allow the detection of early enhancement 1.

Limitations
  • spatial resolution is often lower than conventional T2-weighted sequences.
  • there may be a variation in sensitivity according to zonal anatomy 3.
Assessment

A type III wash-out curve (time intensity curve): early faster enhancement followed by decreasing enhancement over time) is a concerning feature.

See also


Prostate pathology
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Article Information

rID: 48479
System: Urogenital
Synonyms or Alternate Spellings:
  • Dynamic contrast enhancement in prostate cancer: MRI
  • MRI dynamic contrast enhancement in prostate cancer
  • DCE in prostate cancer

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