Last revised by Daniel J Bell on 10 Jul 2023

Dyscrasia (plural: dyscrasias) was used historically in medicine to refer to an imbalance of the four bodily humors 1. It is now used as a synonym for disease, and is only found as part of the terms "blood dyscrasia" or "plasma cell dyscrasia".

Blood dyscrasia refers to any disease of the blood, usually those in which the primary abnormality is of the blood cells.

Plasma cell dyscrasia is characterized by the early finding of monoclonal heavy and light chain restricted antibodies, known as paraprotein or M protein in the human body before the appearance of clinical symptoms. The presence of clonal M protein in blood or urine is known as "monoclonal gammopathy" which can be either due to plasma cell or lymphoid cell proliferation.

Plasma cell dyscrasia is divided into several subtypes namely 2:

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