Dysmyelinating disorders
Citation, DOI, disclosures and article data
At the time the article was created Jeremy Jones had no recorded disclosures.
View Jeremy Jones's current disclosuresAt the time the article was last revised Frank Gaillard had no recorded disclosures.
View Frank Gaillard's current disclosures- dysmyelination
- Dysmyelinating diseases
- Dysmyelinating disease
- Dysmyelinating disorder
Dysmyelinating disorders are a subset of white matter disorders characterized by abnormal myelination 1. They include numerous inherited conditions that are characterized by a defective structure and function of the myelin sheath 2.
Terminology
Dysmyelinating disorders are often thought of being synonymous with leukodystrophies, and traditionally they have been thought of as being distinct from demyelinating disorders where there is destruction or damage of previously normal myelination.
More recently it has become apparent that many of the more common leukodystrophies (e.g. metachromatic leukodystrophy, X-linked adrenoleukodystrophy) have a significant demyelinating component 3,4.
As such is best to think of dysmyelinating and demyelinating as describing the dominant process involved in the larger group of leukodystrophies.
References
- 1. Brant WE, Helms CA. Fundamentals of Diagnostic Radiology. Lippincott Williams & Wilkins. (2007) ISBN:0781761352. Read it at Google Books - Find it at Amazon
- 2. Prayson RA. Neuropathology Review. Humana Press. ISBN:1588298957. Read it at Google Books - Find it at Amazon
- 3. Cheon JE, Kim IO, Hwang YS, Kim KJ, Wang KC, Cho BK, Chi JG, Kim CJ, Kim WS, Yeon KM. Leukodystrophy in children: a pictorial review of MR imaging features. (2002) Radiographics : a review publication of the Radiological Society of North America, Inc. 22 (3): 461-76. doi:10.1148/radiographics.22.3.g02ma01461 - Pubmed
- 4. Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry Schroeder, Anthony J. Frew, Cornelia M. Weyand. Clinical Immunology,Principles and Practice (Expert Consult - Online and Print),4. (2013) ISBN: 9780723436911
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