Early DWI reversal in ischaemic stroke

Early DWI reversal in ischaemic stroke (also referred to as diffusion lesion reversal) is encountered early in the course of ischaemic infarction, most frequently in the setting of reperfusion within 3 to 6 hours of onset 1. In the vast majority of cases it is transient and does not represent true reversal (i.e. the region of the brain initially demonstrating reduced ADC values goes on to infarct regardless of whether early DWI reversal is demonstrated) 1, 2

It should be noted that in other clinical contexts (e.g. hemiplegic migraine, seizures, transient ischaemic attack and transient global amnesia) permanent diffusion lesion reversal, without progression to permanent lesion has been rarely encountered 3

Note: Early DWI reversal should not be confused with ADC pseudonormalisation which occurs later in the evolution of ischaemic stroke. 

Stroke and intracranial haemorrhage
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Article information

rID: 41739
Tag: cases
Synonyms or Alternate Spellings:
  • Diffusion lesion reversal
  • Early diffusion lesion reversal
  • Early diffusion reversal in ischaemic stroke

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