Ears of the lynx sign (brain)
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The ears of the lynx sign refers to abnormal T2/FLAIR cone-shaped hyperintensity at the tip of the frontal horn of the lateral ventricles in the region of forceps minor which resembles the tufts of hair crowning the ears of a lynx.
This sign is seen in hereditary spastic paraplegia with thin corpus callosum (HSP-TCC), a form of hereditary spastic paraplegia associated with mutations of the spastic paraparesis gene 11 (SPG11) on chromosome 15 1,2. The spatacsin vesicle trafficking associated (SPG11) gene, codes spatacsin. The sign may also be seen in SPG15, another of the hereditary spastic paraplegias, which is caused by a mutation in the zinc finger fyve domain-containing protein 26 (ZFYVE26) gene, encoding spastizin. This sign has also been described in Marchiafava-Bignami disease 3.
- a normal variant, commonly seen
- can appear similar but usually less pronounced
- 1. Riverol M, Samaranch L, Pascual B et al. Forceps Minor Region Signal Abnormality “Ears of the Lynx”: An Early MRI Finding in Spastic Paraparesis with Thin Corpus Callosum and Mutations in the Spatacsin Gene(SPG11)on Chromosome 15. Journal of Neuroimaging. 2009;19(1):52-60. doi:10.1111/j.1552-6569.2008.00327.x
- 2. Pascual B, de Bot S, Daniels M et al. “Ears of the Lynx” MRI Sign Is Associated with SPG11 and SPG15 Hereditary Spastic Paraplegia. AJNR Am J Neuroradiol. 2019;40(1):199-203. doi:10.3174/ajnr.a5935
- 3. Pacheco F, Rego M, do Rego J, da Rocha A. “Ears of the Lynx” Sign in a Marchiafava-Bignami Patient: Structural Basis and Fiber-Tracking DTI Contribution to the Understanding of This Imaging Abnormality. J Neuroimaging. 2012;24(2):205-7. doi:10.1111/j.1552-6569.2012.00714.x