Ears of the lynx sign (brain)

Last revised by Dalia Ibrahim on 21 Sep 2023

The ears of the lynx sign refers to abnormal T2/FLAIR cone-shaped hyperintensity at the tip of the frontal horn of the lateral ventricles in the region of forceps minor which resembles the tufts of hair crowning the ears of a lynx.

This sign is seen in hereditary spastic paraplegia with thin corpus callosum (HSP-TCC), the commonest form of which is spastic paraplegia 11 (SPG11), a form of hereditary spastic paraplegia associated with mutations of the identically-named spastic paraparesis gene 11 (SPG11) on chromosome 15 which codes for spatacsin 1,2.

The sign may also be seen in:

  • SPG15, another cause of "hereditary spastic paraplegia with thin corpus callosum", which is caused by a mutation in the zinc finger five domain-containing protein 26 (ZFYVE26) gene, encoding spastizin
  • Marchiafava-Bignami disease 3

Differential diagnosis

ADVERTISEMENT: Supporters see fewer/no ads

Cases and figures

  • Figure 1: photo - Canadian lynx
    Drag here to reorder.
  • Case 1
    Drag here to reorder.
  • Case 2
    Drag here to reorder.
  • Case 3
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.