Ears of the lynx sign (brain)

Last revised by Dr Henry Knipe on 23 Sep 2021

The ears of the lynx sign refers to abnormal T2/FLAIR cone-shaped hyperintensity at the tip of the frontal horn of the lateral ventricles in the region of forceps minor which resembles the tufts of hair crowning the ears of a lynx.

This sign is seen in hereditary spastic paraplegia with thin corpus callosum (HSP-TCC), a form of hereditary spastic paraplegia associated with mutations of the spastic paraparesis gene 11 (SPG11) on chromosome 15 1,2. The spatacsin vesicle trafficking associated (SPG11) gene, codes spatacsin. The sign may also be seen in SPG15, another of the hereditary spastic paraplegias, which is caused by a mutation in the zinc finger fyve domain-containing protein 26 (ZFYVE26) gene, encoding spastizin. This sign has also been described in Marchiafava-Bignami disease 3.

Differential diagnosis

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Cases and figures

  • Figure 1: photo - Canadian lynx
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  • Case 1
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  • Case 2
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