Emphysematous cystitis

Emphysematous cystitis (EC) refers to a gas-forming infection of the bladder wall.

The condition is rare and usually confined to certain patient subgroups. Median age affected is 66 years. More common in women, 2:1 F:M 9.

Risk factors include:

  • diabetes mellitus
    • considered the commonest predisposing factor 6
    • may be present in ~50% of cases 2
  • immunocompromised state
  • neurogenic bladder 
  • transplant recipients
  • bladder outlet obstruction 9
  • prolonged catheterization 9

Symptoms and signs are similar to those of non-emphysematous cystitis, and maybe very non-specific, e.g. fever, abdominal ache and diarrhea. More specific urinary symptoms, such as dysuria and hematuria may be present. A history of pneumaturia may be seen but is not common.

Most often the diagnosis is made incidentally during an imaging examination.

Potential complications include:

Emphysematous cystitis may be caused by bacterial or fungal infection. The most common causative organism is E. coli, with other organisms including Enterobacter aerogenes, Klebsiella pneumonia, Proteus mirabilis, Staphylococcus aureus, streptococci, Clostridium perfringens and Candida albicans.

The constituent gases responsible are mainly carbon dioxide, nitrogen, hydrogen and methane 9.

Conventional radiography characteristically shows curvilinear or mottled areas of increased radiolucency in the region of the urinary bladder, separate from more posterior rectal gas. Intraluminal gas will be seen as a gas-fluid level that changes with patient position, and, when adjacent to the non-dependent mucosal surface, may have a cobblestone or “beaded necklace” appearance. This is thought to reflect the irregular thickening produced by submucosal blebs as seen at direct cystoscopy.

CT is a highly sensitive examination that allows early detection of intraluminal or intramural gas. CT is also useful in evaluating other causes of intraluminal gas such as enteric fistula formation from adjacent bowel carcinoma or inflammatory disease.

Can demonstrate echogenic gas within the bladder wall with dirty shadowing artefact. Ultrasound will also commonly demonstrate diffuse bladder wall thickening and increased echogenicity.

Gas within the bladder wall is virtually always due to emphysematous cystitis. Intraluminal gas within the bladder has a more broad differential.
See article: gas in the urinary bladder.

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Article information

rID: 17036
System: Urogenital
Synonyms or Alternate Spellings:
  • Emphysematous infection of the bladder wall
  • Emphysematous bladder wall infection
  • Emphysematous cystitis (EC)
  • Cystitis emphysematosa

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