Citation, DOI and article data
Emphysematous cystitis refers to a gas-forming infection of the bladder wall.
The condition is rare and usually confined to certain patient subgroups. Median age affected is 66 years. More common in women, 2:1 F:M 9.
Risk factors include:
- considered the commonest predisposing factor 6
- may be present in ~50% of cases 2
- immunocompromised state
- neurogenic bladder
- transplant recipients
- bladder outlet obstruction 9
- prolonged catheterization 9
Symptoms and signs are similar to those of non-emphysematous cystitis, and maybe very non-specific, e.g. fever, abdominal ache and diarrhea. More specific urinary symptoms, such as dysuria and hematuria may be present. A history of pneumaturia may be seen but is not common.
Most often the diagnosis is made incidentally during an imaging examination.
Potential complications include:
Emphysematous cystitis may be caused by bacterial or fungal infection. The most common causative organism is E. coli, with other organisms including Enterobacter aerogenes, Klebsiella pneumonia, Proteus mirabilis, Staphylococcus aureus, streptococci, Clostridium perfringens and Candida albicans.
The constituent gases responsible are mainly carbon dioxide, nitrogen, hydrogen and methane 9.
Conventional radiography characteristically shows curvilinear or mottled areas of increased radiolucency in the region of the urinary bladder, separate from more posterior rectal gas. Intraluminal gas will be seen as a gas-fluid level that changes with patient position, and, when adjacent to the non-dependent mucosal surface, may have a cobblestone or “beaded necklace” appearance. This is thought to reflect the irregular thickening produced by submucosal blebs as seen at direct cystoscopy.
CT is a highly sensitive examination that allows early detection of intraluminal or intramural gas. CT is also useful in evaluating other causes of intraluminal gas such as enteric fistula formation from adjacent bowel carcinoma or inflammatory disease.
Can demonstrate echogenic gas within the bladder wall with dirty shadowing artefact. Ultrasound will also commonly demonstrate diffuse bladder wall thickening and increased echogenicity.
Treatment involves urinary catheterization, antibiotic therapy and control of underlying diabetes.
Gas within the bladder wall is virtually always due to emphysematous cystitis. Intraluminal gas within the bladder has a more broad differential. Be careful not to confuse intraluminal gas with fat density due to careless windowing: chyluria may be present.
See article: gas in the urinary bladder.
- 1. Bobba RK, Arsura EL, Sarna PS et-al. Emphysematous cystitis: an unusual disease of the Genito-Urinary system suspected on imaging. Ann. Clin. Microbiol. Antimicrob. 2004;3 : 20. doi:10.1186/1476-0711-3-20 - Free text at pubmed - Pubmed citation
- 2. Grayson DE, Abbott RM, Levy AD et-al. Emphysematous infections of the abdomen and pelvis: a pictorial review. Radiographics. 22 (3): 543-61. Radiographics (full text) - Pubmed citation
- 3. Patel NP, Lavengood RW, Fernandes M et-al. Gas-forming infections in genitourinary tract. Urology. 1992;39 (4): 341-5. Urology (link) - Pubmed citation
- 4. Joseph RC, Amendola MA, Artze ME et-al. Genitourinary tract gas: imaging evaluation. Radiographics. 1996;16 (2): 295-308. Radiographics (abstract) - Pubmed citation
- 5. Mokabberi R, Ravakhah K. Emphysematous urinary tract infections: diagnosis, treatment and survival (case review series). Am. J. Med. Sci. 2007;333 (2): 111-6. Am. J. Med. Sci. (link) - Pubmed citation
- 6. Gheonea IA, Stoica Z, Bondari S. Emphysematous Cystitis. Case report and imaging features. Curr Health Sci J. 2014;38 (4): 191-4. Free text at pubmed - Pubmed citation
- 7. Eken A, Alma E. Emphysematous cystitis: The role of CT imaging and appropriate treatment. Can Urol Assoc J. 2013;7 (11-12): E754-6. doi:10.5489/cuaj.472 - Free text at pubmed - Pubmed citation
- 8. Perlmutter AE, Mastromichaelis M, Zaslau S. Emphysematous cystitis: a case report and literature review. W V Med J. 2005;100 (6): 232-3. Pubmed citation
- 9. Sharma R, Mitra SK, Choudhary A, Majee P. Emphysematous cystitis-gas in bladder: a rare urological emergency. (2015) BMJ case reports. doi:10.1136/bcr-2015-210836 - Pubmed