Empyemas are purulent inflammatory collections within a body cavity. They are similar to abscesses, which arise within parenchymal tissue rather than occupying a pre-existing anatomical space.
Colloquially, the term empyema is used to refer to thoracic empyemas but there are various different types of empyema which are described by the organ affected:
- gallbladder empyema
- subdural empyema
- thoracic empyema
- joint empyema (of any synovial joint)
- empyema cystitis (urinary bladder)
Empyemas are predominantly caused by bacterial infection of fluid within a pre-existing anatomical space. Once significant bacterial translocation has occurred there is significant deposition of fibrin and a reactive inflammatory response which results in the accumulation of pyogenic and fibrous material within the cavity.
The pathogenesis of an empyema usually requires a small stagnant fluid collection which in the case of the gallbladder requires a degree of biliary tract obstruction.
Treatment and prognosis
Like abscesses, as the vascular supply an empyema is poor, antimicrobial treatment on its own is usually insufficient to treat the underlying infection and drainage of the collection is usually required. This is often done percutaneously with ultrasound guidance although open surgical drainage can be necessary in complex cases.
In cases of empyema involving synovial joints surgical washout can often be the preferred treatment method since the preservation of joint surfaces from damage from infection or the post-infectious inflammatory process is important to preserve function.
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- 2. Stark DD, Federle MP, Goodman PC et-al. Differentiating lung abscess and empyema: radiography and computed tomography. AJR Am J Roentgenol. 1983;141 (1): 163-7. doi:10.2214/ajr.141.1.163 - Pubmed citation