Encephalomalacia is term given to describe softening or loss of brain parenchyma with or without surrounding gliosis, as a late manifestation of injury. 

  • asymptomatic 
  • serve as a focus of seizure

Encephalomalacia is the end result of liquefactive necrosis of brain parenchyma following insult, usually occurring after cerebral ischaemia, cerebral infection, haemorrhage, traumatic brain injury, surgery or other insults. It is not synonymous with gliosis, which is the proliferation of glial cells in response to injury.


Follows CSF signal on all sequences.

Share article

Article information

rID: 30580
Section: Pathology
Synonyms or Alternate Spellings:
  • Encephalomalacias

Support Radiopaedia and see fewer ads

Cases and figures

  • Drag
    Case 1
    Drag here to reorder.
  • Drag
    Case 2
    Drag here to reorder.
  • Drag
    Case 3
    Drag here to reorder.
  • Drag
    Case 4: multicystic encephalomalacia
    Drag here to reorder.
  • Drag
    Case 5
    Drag here to reorder.
  • Drag
    Case 6
    Drag here to reorder.
  • Updating… Please wait.

    Alert accept

    Error Unable to process the form. Check for errors and try again.

    Alert accept Thank you for updating your details.