End-diastolic volume

Last revised by Dr Joachim Feger on 26 Oct 2021

The end-diastolic volume (EDV) is referred to as the volume of blood in the left or right ventricle at the end of the diastolic filling phase immediately before the beginning of systole. The end-diastolic volume index (EDVI) is the end-diastolic volume corrected for the body surface area (BSA).

The end-diastolic volume is an essential parameter used for the assessment of cardiac function, namely the calculation of the respective stroke volumes and ejection fraction and the estimation of left or right ventricular preload.

It has a central role in the diagnosis of many cardiac conditions.

Widely-used postprocessing software solutions for cardiac MRI employ a combination of semi-automated feature recognition and manual contour correction based on Simpson’s method (“summation of disks”) 1.

The end-diastolic volume is determined by the sum of the computed left/right ventricular cross-sectional areas determined by the endocardial contours at the end of the diastolic filling phase (chosen as the images with the largest blood volume) accounting for slice thickness and gap 3.

End-diastolic volume index is calculated as: EDVI = EDV/BSA [mL/m2]

Papillary muscles are often included in blood volumes or mass but not in both 1. The ventricular outflow tract should also be included 2

Normal values differ for the left and right ventricle depending on gender and age and with the imaging modality used 1-3. Values above the normal indicate ventricular dilatation, which can be further categorized in mildly moderately or severely dilated.

Normal values are derived from the publication by Kawel-Boehm with papillary muscles included in ventricular volumes 1:

Women (26-83 years):

  • EDV [mL]:           70-155 mL
  • EDVI [mL/m2]:   45-93 mL/m2

Men (16-83 years):

  • EDV [mL]:           83-207 mL
  • EDVI [mL/m2]:   47-107 mL/m2    

Women (20-83 years):

  • EDV [mL]:           68-176 mL
  • EDVI [mL/m2]:   48-104 mL/m2

Men (20-83 years):

  • EDV [mL]:           87-244 mL
  • EDVI [mL/m2]:   53-123 mL/m2

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