Endometrioid carcinoma of the endometrium is the most common histological subtype of endometrial carcinoma accounts for 85-90% of cases. It is considered a type I carcinoma of the uterus with slow progression and a relatively good prognosis. Patients are usually 55 to 65 years old.
Endometrioid carcinoma is arising from precursor endometrial hyperplasia and associated with PTEN gene mutation in 30-90% of cases. They demonstrate a well-defined glandular pattern resembling normal endometrial glands lined by malignant stratified columnar epithelial cells. Higher-grade endometrioid adenocarcinomas have undifferentiated cells with more solid sheets of tumor cells, which are not organized into well-defined glands and are associated with an atrophied endometrium.
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