Endometrioid adenocarcinoma of the endometrium

Endometrioid carcinoma of the endometrium is the most common histological subtype of endometrial carcinoma accounts for 85-90% of cases. It is considered a type I carcinoma of the uterus with slow progression and a relatively good prognosis. Patients are usually 55 to 65 years old. 

Pathology

Endometrioid carcinoma is arising from precursor endometrial hyperplasia and associated with PTEN gene mutation in 30-90% of cases. They demonstrate a well-defined glandular pattern resembling normal endometrial glands lined by malignant stratified columnar epithelial cells. Higher-grade endometrioid adenocarcinomas have undifferentiated cells with more solid sheets of tumor cells, which are not organized into well-defined glands and are associated with an atrophied endometrium.

Article information

rID: 35504
System: Gynaecology
Synonyms or Alternate Spellings:
  • Endometrioid carcinoma of the endometrium
  • Endometrioid carcinoma of endometrium

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Cases and figures

  • Low-power image s...
    Figure 1: histology
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  • Case 1: synchronous uterine and ovarian
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  • Case 2
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