Endometrioid adenocarcinoma of the endometrium
Citation, DOI, disclosures and article data
At the time the article was created Amir Rezaee had no recorded disclosures.
View Amir Rezaee's current disclosuresAt the time the article was last revised Ammar Haouimi had no financial relationships to ineligible companies to disclose.
View Ammar Haouimi's current disclosures- Endometrioid carcinoma of endometrium
- Endometrioid carcinoma of the endometrium
Endometrioid carcinoma of the endometrium is the most common histological subtype of endometrial carcinoma accounts for 85-90% of cases. It is considered a type I carcinoma of the uterus with slow progression and a relatively good prognosis. Patients are usually 55 to 65 years old.
Pathology
Endometrioid carcinoma is arising from precursor endometrial hyperplasia and associated with PTEN gene mutation in 30-90% of cases. They demonstrate a well-defined glandular pattern resembling normal endometrial glands lined by malignant stratified columnar epithelial cells. Higher-grade endometrioid adenocarcinomas have undifferentiated cells with more solid sheets of tumor cells, which are not organized into well-defined glands and are associated with an atrophied endometrium.
References
- 1. Silverberg S. Problems in the Differential Diagnosis of Endometrial Hyperplasia and Carcinoma. Mod Pathol. 2000;13(3):309-27. doi:10.1038/modpathol.3880053
- 2. Robbins, Stanley L. 1915-, Kumar, Vinay, 1944-. Robbins and Cotran Pathologic Basis of Disease. (2010) ISBN: 9781416031215
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