Entorhinal cortex

Last revised by Dr Daniel J Bell on 22 Jan 2021

The entorhinal cortex (plural: cortices) (a.k.a. Brodmann area 28) is located in the mesial temporal lobe and acts as the interface between the hippocampus and the neocortex. It has been considered part of the hippocampal formation (along with Ammon’s horn, subiculum and presubiculum), but is difficult to precisely localize anatomically, with numerous definitions described 2. It occupies the middle portion of the medial temporal region, and includes part of the parahippocampal gyrus and gyrus ambiens 2.  However, increasingly it is defined by its connectivity to the hippocampus 1,2

Having said that the following anatomical boundaries exist, if somewhat ill-defined 1,2:

Fiber density between the rhinal cortex and activated ventrolateral prefrontal regions has been shown to predict episodic memory performance 3.

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Cases and figures

  • Figure 1: entorhinal cortex
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  • Figure 2: relations
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  • Figure 3: neuroanatomy: septal area (diagrams)
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