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At the time the article was created Frank Gaillard had no recorded disclosures.View Frank Gaillard's current disclosures
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Ependymocytes are one of the three types of ependymal cells, which in turn are one of the four principles types of glial cells, and are found lining the ventricular system of the brain and the central canal of the spinal cord 1.
They do not form a water-tight barrier between the cerebrospinal fluid (CSF) and extracellular fluid of the brain parenchyma, rather allowing flow between the two compartments 2.
Ependymocytes have a variable number of cilia and microvilli on their luminal surface 1.
- glial fibrillary acid protein (GFAP): positive (see below) 4
- epithelial membrane antigen (EMA): positive 4
There is debate about the relationship of normal and neoplastic ependymocytes and staining for GFAP. Both neoplastic, and to a lesser degree normal ependymocytes to demonstrate a positive reaction for GFAP 3,4. This may, however, represent a positive reaction to intermediate filaments that are similar, rather than to GFAP itself which is absent in normal adult ependymocytes 3.