Episodic angioedema with eosinophilia

Dr Daniel J Bell et al.

Episodic angioedema with eosinophilia (EAE), also known as Gleich syndrome, is a rare condition presenting as a self-limiting cyclic urticaria, fever, angioedema, weight gain and marked eosinophilia, with 3-4 weekly episodes 1.

Episodic angioedema with eosinophilia is rare, only about 50 cases have been published in the literature to date.

Typically an episodic condition with new attacks every month or so, which self-resolve without any external interventions being needed.

  • urticaria
  • fever
  • angioedema
  • weight gain (~15-20% body weight)
  • marked eosinophilia

It generally spontaneously resolves, although when presentation is severe, steroids are sometimes administered to quicken recovery. 

Its natural history is benign with no known involvement of the internal viscera.

The first four cases were reported by an American immunologist Gerald J Gleich and colleagues in 1984 2.

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Article information

rID: 73659
System: Haematology
Section: Syndromes
Synonyms or Alternate Spellings:
  • Episodic angioedema with eosinophilia (EAE)
  • Gleich's syndrome
  • Gleich syndrome

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