Epithelial membrane antigen (EMA)

Last revised by Joachim Feger on 28 Feb 2021

Citation, DOI, disclosures and article data

Citation:

Gaillard F, Feger J, Epithelial membrane antigen (EMA). Reference article, Radiopaedia.org (Accessed on 09 Dec 2023) https://doi.org/10.53347/rID-51743

DOI:

https://doi.org/10.53347/rID-51743

Permalink:

https://radiopaedia.org/articles/51743

rID:

51743

Article created:

6 Mar 2017, Frank Gaillard ◈

Disclosures:

At the time the article was created Frank Gaillard had no recorded disclosures.

View Frank Gaillard's current disclosures

Last revised:

28 Feb 2021, Joachim Feger ◉

Disclosures:

At the time the article was last revised Joachim Feger had no recorded disclosures.

View Joachim Feger's current disclosures

Revisions:

2 times, by 2 contributors - see full revision history and disclosures

Systems:

Central Nervous System

Sections:

Pathology

Epithelial membrane antigen (EMA) also known as CD227, MUC1 or episialin is a cell surface mucin glycoprotein found on many ductal and glandular epithelial cells and some hematopoietic cells.

Usage

It serves as a target in immunohistochemistry where it is a common epithelial marker and expressed by many adenocarcinomas with a poor prognosis beyond that it is expressed by meningiomas, Paget disease, epithelioid sarcomas and synovial sarcomas It also is sometimes seen within the cytoplasm of cells (e.g. perinuclear dot in ependymomas) ^1-5.