Epithelial membrane antigen (EMA)

Last revised by Joachim Feger on 28 Feb 2021

Epithelial membrane antigen (EMA) also known as CD227, MUC1 or episialin is a cell surface mucin glycoprotein found on many ductal and glandular epithelial cells and some hematopoietic cells.


It serves as a target in immunohistochemistry where it is a common epithelial marker and expressed by many adenocarcinomas with a poor prognosis beyond that it is expressed by meningiomas, Paget disease, epithelioid sarcomas and synovial sarcomas It also is sometimes seen within the cytoplasm of cells (e.g. perinuclear dot in ependymomas1-5.

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