Epithelioid hemangioendothelioma

Last revised by Dr Dalia Ibrahim on 20 Jun 2021

Epithelioid hemangioendothelioma (EHE) is a rare relatively low grade vascular tumor. It occurs around medium to large venous structures.

It consists of rounded or slightly spindle-shaped eosinophilic endothelial (epitheloid) cells with rounded nuclei and prominent cytoplasmic vacuolisation. 

  • factor VII-associated antigen

It can occur in a number of sites

Please refer to individual location-specific entities for specific features.

It was initially described by SW Weiss and FM Enzinger in 1982 2.

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Cases and figures

  • Case 1: hepatic epithelioid haemagioendothelioma
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  • Case 2: thigh epithelioid hemangioendothelioma
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  • Case 3:hepatic and pulmonary epithelioid hemangioendothelioma
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