Epithelioid hemangioendothelioma

Last revised by Yuranga Weerakkody on 1 Apr 2023

Epithelioid hemangioendothelioma (EHE) is a rare relatively low grade vascular tumor. It occurs around medium to large venous structures.

It consists of rounded or slightly spindle-shaped eosinophilic endothelial (epithelioid) cells with rounded nuclei and prominent cytoplasmic vacuolisation. 

  • factor VII-associated antigen

It can occur in a number of sites

Please refer to individual location-specific entities for specific features.

It was initially described by SW Weiss and FM Enzinger in 1982 2.

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