Extramedullary haematopoiesis

Radswiki et al.

Extramedullary haematopoiesis is a response to erythropoiesis failure in bone marrow. Extramedullary haematopoiesis occurs in haemoglobinopathies, myeloproliferative disorders, or bone marrow infiltration. It  occurs most often in the spleen and liver and occasionally in the lymph nodes. Less common organs include the pleura, lungs, gastrointestinal tract, breast, skin, brain, kidneys, and adrenal glands.

Pathology

Aetiology

Radiographic features

Where extramedullary haematopoiesis involves an organ, there is usually radiographic evidence of its enlargement, e.g. hepatomegaly, splenomegaly visualised by ultrasound, CT or MRI.  Lesions are typically hypermetabolic and hence is FDG-18 avid on PET-CT.4

 However, in the less common situation where extramedullary haematopoiesis involves other tissues within the thorax, they can be seen as a posterior mediastinal mass. These are paraspinal masses that may be unilateral or bilateral and have smooth, sharply delineated, often lobulated margins.

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Article Information

rID: 12220
Synonyms or Alternate Spellings:
  • Extramedullary-haematopoeisis
  • Extramedullary hematopoiesis
  • Extra-medullary haematopoiesis (EMH)
  • Extra-medullary haematopoiesis
  • Extramedullary haematopoiesis (EMH)

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