Extramedullary haematopoiesis

Radswiki et al.

Extramedullary haematopoiesis is a response to erythropoiesis failure in bone marrow.

When involving an organ, extramedullary haematopoiesis causes viceromegaly occurring most often in the spleen (splenomegaly) and liver (hepatomegaly) and occasionally in the lymph nodes.  Viceromegaly is best evaluated via ultrasound, CT or MRI.  Lesions are typically hypermetabolic and is FDG-18 avid on PET-CT.4

Extramedullary haematopoiesis less commonly affects the pleura, lungs, gastrointestinal tract, breast, skin, brain, kidneys, and adrenal glands.

However, in the less common situation where extramedullary haematopoiesis involves other tissues within the thorax, they can be seen as a posterior mediastinal mass. These paraspinal masses may be uni- or bilateral and have smooth, sharply delineated, often lobulated margins.

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Article Information

rID: 12220
Synonyms or Alternate Spellings:
  • Extramedullary-haematopoeisis
  • Extramedullary hematopoiesis
  • Extra-medullary haematopoiesis (EMH)
  • Extra-medullary haematopoiesis
  • Extramedullary haematopoiesis (EMH)

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