Extrapontine myelinolysis (EPM) is one of the complications occurring secondary to rapid correction of hyponatraemia, and is, along with central pontine myelinolysis encompassed by the more recent term osmotic demyelination syndrome.
In the vast majority of cases it is associated with central pontine myelinolysis, rarely it can occur as an isolated entity.
In extrapontine myelinolysis sites include:
- 1. Martin RJ. Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes. J. Neurol. Neurosurg. Psychiatr. 2004;75 Suppl 3 (suppl 3): iii22-8. doi:10.1136/jnnp.2004.045906 - Free text at pubmed - Pubmed citation
- 2. Huin E, Tan KP. CT and MR findings in central pontine and extrapontine myelinolysis-a study of two patients. Singapore Med J. 1997;37 (6): 622-6. Pubmed citation
- 3. Brown WD, Caruso JM. Extrapontine myelinolysis with involvement of the hippocampus in three children with severe hypernatremia. J. Child Neurol. 1999;14 (7): 428-33. Pubmed citation