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Extrapontine myelinolysis

Last revised by Arlene Campos on 9 May 2024

Extrapontine myelinolysis (EPM) is one of the complications occurring secondary to rapid correction of hyponatremia, and is, along with central pontine myelinolysis encompassed by the term osmotic demyelination syndrome.

In the vast majority of cases, it is associated with central pontine myelinolysis but it can also (rarely) occur as an isolated entity.

Pathology

Location

In extrapontine myelinolysis, sites of involvement include:

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