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Citation:
Gaillard F, Saber M, Exuberant honeycombing sign (usual interstitial pneumonia). Reference article, Radiopaedia.org (Accessed on 05 Dec 2024) https://doi.org/10.53347/rID-179617
The exuberant honeycombing sign is an HRCT finding typically observed in the context of usual interstitial pneumonia. This sign is characterized by the presence of extensive honeycomb-like cyst formation within the lungs, comprising more than 70% of the fibrotic portions of the lungs. In other words, there is relatively little (<30%) fibrotic but not-honeycombed lung parenchyma 1-3.
In the context of usual interstitial pneumonia, the presence of the exuberant honeycombing sign, along with the anterior upper lobe sign and the straight-edge sign, has a fairly high specificity but moderate sensitivity for being the result of connective tissue disease-associated interstitial lung disease (CTD-ILD) rather than idiopathic pulmonary fibrosis (IPF) 1,3.
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1. Chung J, Cox C, Montner S et al. CT Features of the Usual Interstitial Pneumonia Pattern: Differentiating Connective Tissue Disease–Associated Interstitial Lung Disease From Idiopathic Pulmonary Fibrosis. AJR Am J Roentgenol. 2018;210(2):307-13. doi:10.2214/ajr.17.18384 - Pubmed
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2. Mohning M, Richards J, Huie T. Idiopathic Pulmonary Fibrosis: The Radiologist’s Role in Making the Diagnosis. BJR. 2019;92(1099):20181003. doi:10.1259/bjr.20181003 - Pubmed
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3. Brady D, Berkowitz E, Sharma A et al. CT Morphologic Characteristics and Variant Patterns of Interstitial Pulmonary Fibrosis in Systemic Lupus Erythematosus. Radiology: Cardiothoracic Imaging. 2021;3(4):e200625. doi:10.1148/ryct.2021200625 - Pubmed
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