Last revised by Daniel J Bell on 27 Apr 2024

F-18 DOPA (3,4-dihydroxy-6-[18F]fluoro-L-phenylalanine) is a PET radiotracer primarily used in the evaluation of neuropsychiatric diseases, movement disorders, and brain malignancies 1


L-DOPA is the non-proteinogenic amino acid precursor to dopamine, with F-18 DOPA usually being synthesized by a nucleophilic substitution reaction.

Clinical uses

F-18 DOPA has mainly been used in the assessment of Parkinson disease 2, schizophrenia and gliomas 4.  It is also used for pheochromocytoma, extra-adrenal abdominal paraganglioma and congenital hyperinsulinemia 3,5,6.

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