Face of the giant panda sign (midbrain)

Last revised by Rohit Sharma ◉ on 28 Oct 2024

Citation, DOI, disclosures and article data

Citation:

Gaillard F, Sharma R, Deng F, et al. Face of the giant panda sign (midbrain). Reference article, Radiopaedia.org (Accessed on 18 Jan 2025) https://doi.org/10.53347/rID-4439

DOI:

https://doi.org/10.53347/rID-4439

Permalink:

https://radiopaedia.org/articles/4439?iframe=true

rID:

4439

Article created:

25 Aug 2008, Frank Gaillard ◉ ◈

Disclosures:

At the time the article was created Frank Gaillard had no recorded disclosures.

View Frank Gaillard's current disclosures

Last revised:

28 Oct 2024, Rohit Sharma ◉

Disclosures:

At the time the article was last revised Rohit Sharma had no financial relationships to ineligible companies to disclose.

View Rohit Sharma's current disclosures

Revisions:

12 times, by 9 contributors - see full revision history and disclosures

Systems:

Central Nervous System

Sections:

Signs

Tags:

cases

Synonyms:

Panda sign of the midbrain
Panda face sign (Wilson disease)

The face of the giant panda sign in neuroimaging refers to the appearance of the midbrain, when the red nucleus and substantia nigra are surrounded by high T2 signal in the tegmentum.

It is classically seen in Wilson disease, although whenever the white matter is diffusely abnormal in the region a similar appearance will be perceived. As such, the sign may also be appreciated in ^5-7:

viral encephalitis, e.g. Japanese encephalitis, West Nile virus encephalitis
toxic leukoencephalopathy, e.g. methanol poisoning, methotrexate-related leukoencephalopathy
osmotic demyelination syndrome (extrapontine myelinolysis)

Face of the giant panda sign (midbrain)

Citation, DOI, disclosures and article data

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