Familial atypical multiple mole melanoma syndrome

Familial atypical multiple mole melanoma (FAMMM) syndrome is an autosomal dominant genodermatosis characterized by multiple melanocytic nevi (often more than 50) and a family history of melanoma.

Pathology

Genetics

It is associated with mutations in the CDKN2A gene and shows reduced penetrance and variable expressivity.

Associations

Some FAMMM patients show an increased risk for the development of pancreatic adenocarcinoma and possibly other malignancies.

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Article information

rID: 69146
Section: Syndromes
Synonyms or Alternate Spellings:
  • FAMMM syndrome
  • Hereditary dysplastic nevus syndrome
  • Familial atypical multiple mole melanoma (FAMMM) syndrome
  • Familial atypical multiple mole melanoma syndrome
  • Familial atypical multiple mole melanoma (FAMMM)

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