Familial medullary thyroid carcinoma

Last revised by Dr Matt Adams on 09 May 2021

Familial medullary thyroid carcinoma (FMTC) is a genetic disorder closely related to multiple endocrine neoplasia type IIa (MEN2a) and multiple endocrine neoplasia type IIb (MEN2b). It is characterised by the development of medullary thyroid cancer.  

FMTC is the result of mutations in the RET (rearranged during transfection) proto-oncogene (10q11.2) and is inherited in an autosomal dominant fashion 1. Unlike other multiple endocrine neoplasia syndromes, FMTC exclusively involves the thyroid gland 1

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