Fat redistribution syndrome

Assoc Prof Craig Hacking and Radswiki et al.

The fat redistribution syndrome (or HIV lipodystrophy syndrome) is seen in a number of AIDS patients on HAART. It is characterized by typical changes in body fat distribution.

Features include :

  • hypertrophy in the neck fat pad (buffalo hump)
  • increased fat in the abdominal region (protease paunch)
  • gynecomastia
  • loss of fat in the midface and extremities.

Biochemically, these patients have increased triglycerides, total cholesterol, low-density lipoprotein-cholesterol, and extremely low high-density lipoprotein-cholesterol.

If left untreated, these patients develop and die of complications of metabolic origin such as cardiovascular diseases or diabetes mellitus. Biochemical features manifest before the clinical pictures become apparent.

Differential diagnosis

For hypertrophy of the fat around the neck consider:

Article information

rID: 12642
Tag: hiv, aids
Synonyms or Alternate Spellings:
  • HIV lipodystrophy syndrome

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Cases and figures

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