Fatal familial insomnia
Last revised by Matthew Lukies
on 14 Jun 2018
Citation, DOI, disclosures and article data
Citation:
Mousavi F, Lukies M, Bell D, et al. Fatal familial insomnia. Reference article, Radiopaedia.org (Accessed on 07 Dec 2024) https://doi.org/10.53347/rID-53607
Permalink:
rID:
53607
Article created:
26 May 2017,
Foroogh Jafari Mousavi ◉
Disclosures:
At the time the article was created Foroogh Jafari Mousavi had no recorded disclosures.
View Foroogh Jafari Mousavi's current disclosures
Last revised:
14 Jun 2018,
Matthew Lukies
Disclosures:
At the time the article was last revised Matthew Lukies had no recorded disclosures.
View Matthew Lukies's current disclosures
Revisions:
5 times, by
5 contributors -
see full revision history and disclosures
Systems:
Synonyms:
- FFI
Fatal familial insomnia is an extremely rare autosomal dominant inherited prion disease 1. Unlike other prion diseases, it does not exhibit spongiform changes. The main pathological findings are gliosis in the inferior olivary nuclei and thalami.
References
- 1. McKusick, V. A., O. Hurko, M. Smith, S. A. Rasmussen, and CL Kniffin. "FATAL FAMILIAL INSOMNIA; FFI." Online Mendelian Inheritance in Man. Johns Hopkins University, 25 Sept. 2012. Web. 27 May 2017. .
- 2. Medori R, Tritschler HJ, LeBlanc A, Villare F, Manetto V, Chen HY, Xue R, Leal S, Montagna P, Cortelli P. Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene. The New England journal of medicine. 326 (7): 444-9. doi:10.1056/NEJM199202133260704 - Pubmed
- 3. Krasnianski A, Bartl M, Sanchez Juan PJ, Heinemann U, Meissner B, Varges D, Schulze-Sturm U, Kretzschmar HA, Schulz-Schaeffer WJ, Zerr I. Fatal familial insomnia: Clinical features and early identification. Annals of neurology. 63 (5): 658-61. doi:10.1002/ana.21358 - Pubmed
- 4. Rakesh K Gupta. Magnetic Resonance Imaging of Neurological Diseases in Tropics. ISBN: 9789350909720
- 5. Eric Nofzinger, Pierre Maquet, Michael J Thorpy. Neuroimaging of Sleep and Sleep Disorders. ISBN: 9781107018631
- 6. Massimo Filippi. Oxford Textbook of Neuroimaging (Oxford Textbooks in Clinical Neurology). Oxford Press (2015). ISBN: 9780199664092
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