FDDNP (F-18)
Last revised by Andrew Murphy on 11 Sep 2020
Citation, DOI, disclosures and article data
Citation:
Gajera J, Murphy A, FDDNP (F-18). Reference article, Radiopaedia.org (Accessed on 25 Apr 2024) https://doi.org/10.53347/rID-81729
rID:
81729
Article created:
1 Sep 2020,
Jay Gajera ◈
Disclosures:
At the time the article was created Jay Gajera had no recorded disclosures.
View Jay Gajera's current disclosures
Last revised:
11 Sep 2020,
Andrew Murphy ◉
Disclosures:
At the time the article was last revised Andrew Murphy had no recorded disclosures.
View Andrew Murphy's current disclosures
Revisions:
2 times, by
2 contributors -
see full revision history and disclosures
[F-18] FDDNP formally known as, 2-(1-{6-[(2-[fluorine-18]fluoroethyl)(methyl)amino]-2-naphthyl}-ethylidene)malononitrile is the first positron emission tomography (PET) molecular imaging radiotracer to visualize neurofibrillary tangles within the brain. It has been employed in the research setting to visualize and quantify in-vivo Alzheimer disease (AD) pathology, tauopathies, and chronic traumatic encephalopathy.
References
- 1. Jorge R. Barrio, Gary W. Small, Koon-Pong Wong, Sung-Cheng Huang, Jie Liu, David A. Merrill, Christopher C. Giza, Robert P. Fitzsimmons, Bennet Omalu, Julian Bailes, Vladimir Kepe. In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging. (2015) Proceedings of the National Academy of Sciences. 112 (16): E2039. doi:10.1073/pnas.1409952112 - Pubmed
- 2. Small G et. al. PET scanning of brain tau in retired national football league players: preliminary findings. (2013) The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. doi:10.1016/j.jagp.2012.11.019 - Pubmed
- 3. Smid L et. al. Postmortem 3-D brain hemisphere cortical tau and amyloid-β pathology mapping and quantification as a validation method of neuropathology imaging. (2020) Journal of Alzheimer's disease : JAD. doi:10.3233/JAD-122434 - Pubmed
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