Felty syndrome

Felty syndrome comprises of the combination of:

It is thought to occur in ~ 1% of patients with rheumatoid arthritis 2.

Serological markers
  • rheumatoid factor (RF): Over 95% of FS patients are positive 5
  • antinuclear antibody (ANA): 47-100% are positive 5
  • HLA-DR4*0401 antigen: 78% of patients have the antigen 5
  • large granular lymphocyte (LGL) expansion: ~ 30% of patients may have it 5

Patient may have recurrent infections due to the neutropaenia.

It is named after Augustus Roi Felty: American (US) physician (1895 -1964) 1

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Article Information

rID: 10600
Synonyms or Alternate Spellings:
  • Felty's syndrome
  • Felty syndrome (FS)

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