Felty syndrome

Felty syndrome is a rare hematological syndrome in rheumatoid arthritis.

It is thought to occur in ~ 1% of patients with rheumatoid arthritis 2.

Felty syndrome comprises of the triad of:

Additionally, patients may have bicytopaenia or pancytopaenia, recurrent bacterial infections, and non-cirrhotic portal hypertension.

  • rheumatoid factor (RF): >95% of patients are positive 5
  • antinuclear antibody (ANA): 47-100% are positive 5
  • HLA-DR4*0401 antigen: 78% of patients have the antigen 5
  • large granular lymphocyte (LGL) expansion: ~ 30% of patients may have it 5

Treatment is through immunosuppression to treat Felty syndrome and rheumatoid arthritis, such as use of methotrexate and rituximab 6. If frequent severe bacterial infections, G-CSF may be administered 6.

It is named after Augustus Roi Felty (1895 -1964), an American physician 1.

Article information

rID: 10600
Section: Syndromes
Synonyms or Alternate Spellings:
  • Felty's syndrome
  • Felty syndrome (FS)

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