Felty syndrome comprises of the combination of:
It is thought to occur in ~ 1% of patients with rheumatoid arthritis 2.
- rheumatoid factor (RF): Over 95% of FS patients are positive 5
- antinuclear antibody (ANA): 47-100% are positive 5
- HLA-DR4*0401 antigen: 78% of patients have the antigen 5
- large granular lymphocyte (LGL) expansion: ~ 30% of patients may have it 5
Patient may have recurrent infections due to the neutropenia.
History and etymology
It is named after Augustus Roi Felty: American (US) physician (1895 -1964) 1
- 1. A. R. Felty. Chronic arthritis in the adult, associated with splenomegaly and leucopenia. A report of 5 cases of an unusual clinical syndrome. Bulletin of the Johns Hopkins Hospital, Baltimore, 1924, 35: 16.
- 2. WJ Shih et.al, Radiocolloid scintigraphy in Felty's syndrome, AJR ; Vol 147, Issue 1, 181-183, 1986
- 3 Jain T, Mittal C, Sengupta R, Rubin B. Non-articular Felty's syndrome: An uncommon diagnosis. The Netherlands journal of medicine. 73 (9): 435-6. Pubmed
- 4. Rozin A, Hoffman R, Hayek T, Balbir-Gurman A. Felty's syndrome without rheumatoid arthritis?. Clinical rheumatology. 32 (5): 701-4. doi:10.1007/s10067-012-2157-3 - Pubmed
- 5. Balint GP, Balint PV. Felty's syndrome. Best practice & research. Clinical rheumatology. 18 (5): 631-45. doi:10.1016/j.berh.2004.05.002 - Pubmed